Mark L. Shibuya

US Patent 7172739 Protein fractionation

US Patent 7179591 Method and apparatus for combinatorial chemistry

US Patent 7179894 Combinatorial selection of oligonucleotide aptamers

US Patent 7195866 Production of anti-self antibodies from antibody segment repertoires and displayed on phage

US Patent 7202033 Identification of kinase inhibitors

US Patent 7217738 β2-adrenergic receptor agonists

US Patent 7220548 Partial homologous recombination of DNA chain

US Patent 7223547 Polypeptides having a functional domain of interest and methods of identifying and using same

US Patent 7232798 Neuroprotection and neuroegenisis by administering cyclic prolyl glycine

US Patent 7238662 Alpha 2HS glycoprotein for treatment of cancer and a method for preparation thereof

US Patent 7241565 Liquid interface configurations for automated patch clamp recording

US Patent 7242000 Method and apparatus for screening combinatorial libraries of semiconducting properties

US Patent 7244572 One-dimensional arrays on optical fibers

US Patent 7244611 Methods and devices for hybridization and binding assays using thermophoresis

US Patent 7250534 Performance of energy storage devices: potential areas for dendritic chemistry involvement

US Patent 7252950 Assays for detecting modulators of cytoskeletal function

US Patent 7267947 Array-based detection of genetic alterations associated with disease

US Patent 7285573 Use of creatine or creatine analogs for the treatment of diseases of the nervous system

US Patent 7288367 Non-mevalonate isoprenoid pathway

US Patent 7294457 Direct binding assay for identifying inhibitors of HCV polymerase

US Patent 7297478 Creation of variable length and sequence linker regions for dual-domain or multi-domain molecules

US Patent 7297491 Methods and compositions for interaction trap assays

US Patent 7300756 Epoxide polymer surfaces

US Patent 7303750 Methods to improve immunogenicity of antigens and specificity of antibodies

US Patent 7303768 Preparation of aqueous clear solution dosage forms with bile acids

US Patent 7306923 Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases

US Patent 7307058 Multimeric Apo A-I agonist compounds

US Patent 7309759 Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics

US Patent 7312190 Pharmaceutical compositions of apolipoprotein A-I agonists and their use to treat dyslipidemic disorders

US Patent 7314620 Methods for diagnosis and treatment of PH domain signal transduction disorders

US Patent 7316897 Process, device and reagent for cell separation

US Patent 7319012 Protein arrays and methods and systems for producing the same

US Patent 7323306 Genome signature tags

US Patent 7323320 Microarray synthesis and assembly of gene-length polynucleotides

US Patent 7326707 Bicyclic melanocortin-specific compounds

US Patent 7326954 Scaffold-organized metal, alloy, semiconductor and/or magnetic clusters and electronic devices made using such clusters

US Patent 7329725 Phage displayed Trp cage ligands

US Patent 7329742 Aptamers and methods for their in vitro selection and uses thereof

US Patent 7332308 Incrementally truncated nucleic acids and methods of making same

US Patent 7335516 Methods to improve immunogenicity of antigens and specificity of antibodies

US Patent 7338768 Carrier-reporter bead assemblies

US Patent 7341724 Polypeptide for the treatment of cancer and a method for preparation thereof

US Patent 7348144 Methods and system for multi-drug treatment discovery

US Patent 7354704 High throughout screening method and apparatus

US Patent 7367933 Screening of chemical compounds purified from biological sources

US Patent 7374880 Methods of identifying therapeutic compounds in a genetically defined setting

US Patent 7377894 Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules

US Patent 7381315 Multi-channel analyte-separation device employing side-entry excitation

US Patent 7384388 Styryl dyes with linker

US Patent 7384589 Nanoscale molecularly imprinted polymers and method thereof

US Patent 7393318 Methods and compositions for interaction trap assays

US Patent 7413538 Epitopes formed by non-covalent association of conjugates

US Patent 7422871 Uropathogenic

US Patent 7427639 β2-adrenergic receptor agonists

US Patent 7429238 Systems and methods for the generation of crystalline polymorphs

US Patent 7429466 Methods and arrays for detecting biological molecules

US Patent 7432307 Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation

US Patent 7442516 Antibody specific to central nervous system tau protein

US Patent 7456203 Muscarinic receptor antagonists

US Patent 7462322 Methods and apparatus for improved luminescence assays

US Patent 7462746 Amino polyols and amino sugars

US Patent 7482128 Anti-feline albumin antibodies

US Patent 7482162 Determination of vitamin D metabolite and displacement from plasma or serum binding proteins

US Patent 7482174 Disease markers for early stage atherosclerosis

US Patent 7482437 Protease inhibitor conjugates and antibodies useful in immunoassay

US Patent 7488608 Reduction of non-specific binding in assays

US Patent 7491817 Universal supports for oligonucleotide synthesis

US Patent 7494780 Epididymis-specific defensin for evaluating and regulating male fertility

US Patent 7494820 Electrochemiluminescence of rare earth metal chelates

US Patent 7504072 Biopolymeric array scanning devices that focus on the far side of an array and methods for using the same

US Patent 7504262 High sensitivity biomolecule detection with magnetic particles

US Patent 7504364 Methods of making arrays and artificial receptors

US Patent 7504365 Combinatorial artificial receptors including tether building blocks

US Patent 7507550 Analytical sandwich test for determining NT-proBNP

US Patent 7511123 Immuno-interactive fragments of the alpha-C subunit of inhibin

US Patent 7514226 Antibody pair screening methods

US Patent 7514227 Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnostic kit for cardiac disease

US Patent 7514270 Immunoassay probe

US Patent 7517699 Positive detection lateral-flow apparatus and method for small and large analytes

US Patent 7517701 Luminescent lanthanide complexes

US Patent 7527980 Indirect detection of cardiac markers for assessing acute myocardial infarction

US Patent 7527981 Bioweapon-detecting fibrous-network products and methods for making same

US Patent 7537938 Biomarker detection in circulating cells

US Patent 7550269 PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies

US Patent RE40835 Enhancement of immunochemical staining in aldehyde-fixed tissue

US Patent 7556928 Method of screening a population of cells

US Patent 7560257 Diagnostic methods for age related macular degeneration

US Patent 7560289 Methods of quantitatively measuring biomolecules

US Patent 7566541 Diagnostic method for screening complement regulatory protein levels to predict spontaneous abortion

US Patent 7566549 Immunoassay for LSD and 2-oxo-3-hydroxy-LSD

US Patent 7569338 Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions

US Patent 7569353 Myeloperoxidase detection in diagnosis and prognosis of hematopoietic disorders

US Patent 7569398 Methods and devices for transporting and concentrating an analyte present in a sample

US Patent 7585682 Magnetic in situ dilution

US Patent 7611480 Gastrointestinal bioreactor

US Patent 7611853 Assay to screen for anti-malarials

US Patent 7615376 Masking background fluorescence and luminescence in the optical analysis of biomedical assays

US Patent 7615382 Magnetic sifter

US Patent 7622077 In situ heat induced antigen recovery and staining apparatus and method

US Patent 7632461 In situ heat induced antigen recovery and staining apparatus and method

US Patent 7651841 Polyelectrolytic internal calibration system of a flow-through assay

US Patent 7651868 Method and system for the analysis of saliva using a sensor array

US Patent 7655184 Delayed and diffused flow rapid confirmatory immunological testing apparatus and method

US Patent 7674632 Method and composition for homogeneous multiplexed microparticle-based assay

US Patent 7682837 Devices and methods to form a randomly ordered array of magnetic beads and uses thereof

US Patent 7682838 Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

US Patent 7696329 Immunoglobulin peptides against heated bovine blood

US Patent 7700372 Portable diagnostic device and method for determining temporal variations in concentrations

US Patent 7709271 Method and device for immunoassay

US Patent 7709273 Particles for diagnostic and therapeutic use

US Patent 7713750 Ablation based laser machining of biomolecule patterns on substrates

US Patent 7713752 Magnetic bead agglomerator for automated ELISA process

US Patent 7718445 Methods and compositions for directed microwave chemistry

US Patent 7723063 Methods for measuring levels of bioactive human hepcidin

US Patent 7723127 Immunoassay with extended dynamic range

US Patent 7728112 Method for monitoring collagen type II degradation in cartilage

US Patent 7732145 Method and devices for rapid diagnosis of foot-and-mouth disease

US Patent 7732217 Apparatus and method for reading fluorescence from bead arrays

US Patent 7732219 Detection and amplification of ligands

US Patent 7732220 Method of analysis of a mixture of biological and/or chemical components with the use magnetic particles and apparatus for its embodiment

US Patent 7741052 Method of assessing the risk of atherosclerosis

US Patent 7745162 Compositions and methods for measuring levels of bioactive human hepcidin

US Patent 7749721 Immuno enzymatic quantification method for cholesterol ester transferring protein (CETP)

US Patent 7749774 Arrays formed of encoded beads having ligands attached

US Patent 7785902 Method for analyzing a mixture of biological and/or chemical components using magnetic particles and device for the implementation of said method

US Patent 7794949 Biomarkers of chronic pelvic pain syndrome

US Patent 7794953 Method and kits for detecting cerebrospinal fluid in a sample

US Patent 7803633 Screening arrangement for screening immunoassay tests and agglutination tests

US Patent 7824876 Method for diagnosing acute coronary syndrome

US Patent 7842463 Method of diagnosing early stage renal impairment

US Patent 7842513 Pregnancy detection

US Patent 7863005 Method for detecting perilymphatic fistula

US Patent 7910383 Molecular fingerprints with enhanced identifying capability, method for preparing same and use thereof

US Patent 7943398 Resonant magnetic disks for bioanalyte detection

US Patent 7964414 Biosensor with suppressed non-specific adsorption