Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Anjana Rao0
Kian Peng Koh0
Mamta Tahiliani0
Suneet Agarwal0
Aravind Iyer0
Date of Patent
June 18, 2019
Patent Application Number
15440815
Date Filed
February 23, 2017
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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