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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Suneet Agarwal0
Anjana Rao0
Aravind Iyer0
Kian Peng Koh0
Mamta Tahiliani0
Date of Patent
July 27, 2021
0Patent Application Number
163808460
Date Filed
April 10, 2019
0Patent Citations
...
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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