Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kian Peng Koh0
Suneet Agarwal0
Anjana Rao0
Aravind Iyer0
Mamta Tahiliani0
Date of Patent
December 17, 2019
0Patent Application Number
160125100
Date Filed
June 19, 2018
0Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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