Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Aravind Iyer0
Mamta Tahiliani0
Suneet Agarwal0
Anjana Rao0
Kian Peng Koh0
Date of Patent
June 25, 2024
0Patent Application Number
176755020
Date Filed
February 18, 2022
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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