US Patent 10548953 Factor VIII-XTEN fusions and uses thereof
Patent 10548953 was granted and assigned to Bioverativ on February, 2020 by the United States Patent and Trademark Office.
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Patent abstract
The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.
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Patent Applicant
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Patent Number
105489530
Date of Patent
February 4, 2020
0Patent Application Number
149120470
Date Filed
August 14, 2014
0Patent Citations Received
Patent Primary Examiner
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Patent Citations Received
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Infobox
Is a
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
105489530
Date of Patent
February 4, 2020
0Patent Application Number
149120470
Date Filed
August 14, 2014
0Patent Primary Examiner
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US Patent 10548953 Factor VIII-XTEN fusions and uses thereof
Infobox
Is a
Patent applicant
Current assignee
Patent jurisdiction
Patent number
10548953
Date of patent
February 4, 2020
Patent application number
14912047
Date Filed
August 14, 2014
Patent primary examiner
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