Patent 11584748 was granted and assigned to C4 Therapeutics on February, 2023 by the United States Patent and Trademark Office.
The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.