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US Patent 11690921 Delivery of target specific nucleases

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 US Patent 11690921 Delivery of target specific nucleases

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Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
116909210
Date of Patent
July 4, 2023
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Patent Application Number
164131440
Date Filed
May 15, 2019
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Patent Citations
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US Patent 7153949 Nucleic acid encoding poly-zinc finger proteins with improved linkers
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US Patent 7163824 Regulation of endogenous gene expression in cells using zinc finger proteins
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US Patent 7166745 Transfection reagents
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US Patent 7173154 Transfection reagents
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US Patent 7262054 Zinc finger proteins for DNA binding and gene regulation in plants
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US Patent 7323594 Transfection reagents
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US Patent 7361635 Simultaneous modulation of multiple genes
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US Patent 7601872 Transfection reagents
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US Patent 7888121 Methods and compositions for targeted cleavage and recombination
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US Patent 7914796 Engineered cleavage half-domains
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US Patent 7915450 Transfection reagents
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US Patent 7951925 Methods and compositions for gene inactivation
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US Patent 8110379 Targeted integration into the PPP1R12C locus
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US Patent 8153773 Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap
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US Patent 8329986 Targeted integration into the
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US Patent 8409861 Targeted deletion of cellular DNA sequences
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US Patent 8563314 Methods and compositions for modulating PD1
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US Patent 8586526 DNA-binding proteins and uses thereof
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US Patent 8597912 Methods and compositions for generation of Bax-and Bak-deficient cell lines
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US Patent 8623618 Engineered cleavage half-domains
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US Patent 8697359 CRISPR-Cas systems and methods for altering expression of gene products
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US Patent 8703489 Methods and compositions for targeted single-stranded cleavage and targeted integration
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US Patent 8771985 Genome editing of a
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US Patent 8785200 Transfection reagents
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US Patent 8871905 Modification of CXCR4 using engineered zinc finger proteins
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US Patent 8895264 Methods and compositions for modification of the
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US Patent 8936936 Methods and compositions for targeted integration
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US Patent 8945868 Methods and compositions for modification of a HLA locus
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US Patent 8956828 Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
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US Patent 8962281 Engineered cleavage half-domains
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US Patent 9005973 Targeted genomic modification with partially single-stranded donor molecules
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US Patent 9045763 Linear donor constructs for targeted integration
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US Patent 9150847 Methods and compositions for regulation of transgene expression
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US Patent 9161995 Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
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US Patent 9200266 Methods and compositions for targeted single-stranded cleavage and targeted integration
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US Patent 9206404 Method of deleting an IgM gene in an isolated rat cell
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US Patent 9222105 Methods and compositions for modification of the HPRT locus
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US Patent 9358300 Transfection reagents
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US Patent 9458205 Modified DNA-binding proteins and uses thereof
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US Patent 9567573 Genome editing of a
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US Patent 9597357 T cell modifying compounds and uses thereof
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US Patent 9816074 Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
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US Patent 9873894 Methods and compositions for treatment of a genetic condition
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US Patent 9877988 Method of treating lysosomal storage diseases using nucleases and a transgene
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US Patent 10143760 Liver-specific constructs, factor VIII expression cassettes and methods of use thereof
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US Patent 10179918 Methods and compositions for increasing transgene activity
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Patent Primary Examiner
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Janet L Epps-Smith
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CPC Code
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C12N 2310/20
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C12N 15/907
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C12N 15/88
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C12N 15/11
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C12N 2800/80
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C12N 9/22
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A61K 48/0008
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A61K 9/5123
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A61K 9/1271
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A61K 35/76
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