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US Patent 11840561 Anti-KRAS-G12D T cell receptors

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Paul F. Robbins0

Anna Pasetto0

Zhili Zheng0

Yong-Chen Lu0

Steven A. Rosenberg0

Eric Tran0

Date of Patent

December 12, 2023

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Patent Application Number

175416190

Date Filed

December 3, 2021

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Patent Citations

US Patent 8383099 Adoptive cell therapy with young T cells

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US Patent 10117918 Antigen-specific T cell receptors and T cell epitopes

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US Patent 10611816 Anti-KRAS-G12D T cell receptors

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US Patent 10556940 T cell receptors recognizing HLA-Cw8 restricted mutated KRAS

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US Patent 11208456 Anti-KRAS-

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US Patent 7709002 Mutated

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US Patent 8034334 Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy

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Patent Primary Examiner

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Patent abstract

Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

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