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US Patent 11920133 RAAV-based compositions and methods

Patent 11920133 was granted and assigned to University of Massachusetts on March, 2024 by the United States Patent and Trademark Office.

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 US Patent 11920133 RAAV-based compositions and methods

Article

Patent abstract

The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Infobox
Is a
Patent
Patent
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Patent Applicant
University of Massachusetts
University of Massachusetts
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Current Assignee
University of Massachusetts
University of Massachusetts
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119201330
Patent Inventor Names
Christian Mueller0
Phillip D. Zamore0
Terence Flotte0
Date of Patent
March 5, 2024
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Patent Application Number
175761300
Date Filed
January 14, 2022
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Patent Citations
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US Patent 7198951 Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
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US Patent 7235393 Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
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US Patent 7387896 MicroRNA vectors
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US Patent 7427396 AAV vectors for gene delivery to the lung
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US Patent 7456015 Tetracycline-regulated adeno-associated viral (AAV) vectors for gene delivery to the nervous system
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US Patent 7906111 Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
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US Patent 8222221 Modulation of gene expression through endogenous small RNA targeting of gene promoters
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US Patent 8524446 Method for detecting adeno-associated virus
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US Patent 8734809 AAV's and uses thereof
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US Patent 9102949 CNS targeting AAV vectors and methods of use thereof
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US Patent 9217155 Isolation of novel AAV'S and uses thereof
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US Patent 9226976 RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
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US Patent 9249424 Intranasal delivery of AAV encoding therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases
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US Patent 9272053 AAV-based treatment of cholesterol-related disorders
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US Patent 9284357 AAV's and uses thereof
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US Patent 9546369 Multicistronic expression constructs
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US Patent 9596835 Isolation of novel AAV's and uses thereof
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US Patent 9885057 RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
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US Patent 10077452 rAAV-based compositions and methods
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US Patent 10166297 Isolation of novel AAV's and uses thereof
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US Patent 10300146 Isolation of novel AAV's and uses thereof
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US Patent 10597656 RAAV-based compositions and methods
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US Patent 10793861 Products and methods for treatment of familial amyotrophic lateral sclerosis
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US Patent 10829783 Multicistronic expression constructs
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US Patent 10905776 Isolation of novel AAV's and uses thereof
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US Patent 11254939 RAAV-based compositions and methods
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US Patent 7022519 Compositions and methods for helper-free production of recombinant adeno-associated viruses
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Patent Primary Examiner
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Amy H Bowman
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CPC Code
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C12N 2310/141
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C12N 15/113
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