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US Patent 11958852 Compounds and methods

Patent 11958852 was granted and assigned to Intra-Cellular Therapies on April, 2024 by the United States Patent and Trademark Office.

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 US Patent 11958852 Compounds and methods

Article

Patent abstract

The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Intra-Cellular Therapies
Intra-Cellular Therapies
0
Current Assignee
Intra-Cellular Therapies
Intra-Cellular Therapies
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119588520
Patent Inventor Names
Kimberly Vanover0
Lawrence Wennogle0
Robert Davis0
Sharon Mates0
Date of Patent
April 16, 2024
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Patent Application Number
174057360
Date Filed
August 18, 2021
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Patent Citations
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US Patent 11124514 Compositions and methods
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US Patent 11096944 Organic compounds
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US Patent 7109339 Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
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US Patent 7115784 Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
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US Patent 7183282 Substituted heterocycle fused γ-carbolines
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US Patent 7223879 Ligands for metals and improved metal-catalyzed processes based thereon
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US Patent RE39679 Substituted heterocycle fused gamma-carbolines
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US Patent RE39680 Substituted heterocycle fused gamma-carbolines
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US Patent 7238690 Substituted heterocycle fused gamma-carbolines
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US Patent 7247731 Ligands for metals and improved metal-catalyzed processes based thereon
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US Patent 7323608 Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
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US Patent 7375226 Bi- and tricyclic substituted phenyl methanones
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US Patent 7462641 (2S,4S)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile
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US Patent 7592454 Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
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US Patent 7601740 Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
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US Patent 8309722 Substituted heterocycle gamma-carbolines synthesis
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US Patent RE48839 Methods and compositions for sleep disorders and other disorders
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US Patent 8598119 Methods and compositions for sleep disorders and other disorders
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US Patent 8648077 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid addition salt and salt crystals
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US Patent 8779139 Substituted 2,3,4,4A,5,9B-hexahydro-1H-pyrido[4,3-B]indole derivatives synthesis and uses thereof
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US Patent 8791138 Compositions and methods for alleviating depression or improving cognition
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US Patent 8993572 Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives
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US Patent 9168258 Methods and compositions for sleep disorders and other disorders
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US Patent 9199995 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid addition salt and salt crystals
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US Patent 9315504 Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof
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US Patent 9371324 Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
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US Patent 9428506 Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
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US Patent 9586960 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms
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US Patent 9616061 Methods and compositions for sleep disorders and other disorders
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US Patent 9708322 Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
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US Patent 9745300 Organic compounds
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US Patent 9751883 Preparation of certain [((6BR,10AS)-2,3,6B,7,8,9,10, 10A-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof
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US Patent 9956227 Method for the treatment of residual symptoms of schizophrenia
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US Patent 10072010 Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
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US Patent 10077267 Organic compounds
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US Patent 10117867 Methods and compositions for sleep disorders and other disorders
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US Patent 10245260 Organic compounds
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US Patent 10322134 Methods
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US Patent 10464938 Pharmaceutical compositions comprising ((6bR,10aS)-1-(4-fluorophenyl)-4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one or pharmaceutically acceptable salts thereof
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US Patent 10472359 Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity
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US Patent 10597394 Organic compounds
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US Patent 10654854 Salts and crystals of ITI-007
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US Patent 10688097 Organic compounds
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US Patent 10702522 Methods and compositions for sleep disorders and other disorders
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US Patent 10716786 Transmucosal and subcutaneous compositions
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US Patent 10799500 Organic compounds
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US Patent 10844061 Pharmaceutical compositions comprising 4-(6BR,10AS)-3-methyl-2,3,6B,9,10,10A-hexahydro-1h, 7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one and methods of treating conditions of the central nervous system
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US Patent 10899762 Organic compounds
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US Patent 10960009 Methods of treating schizophrenia and depression
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US Patent 10960010 Pharmaceutical compositions for sustained or delayed release
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US Patent 11026951 Methods of treating bipolar disorder
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US Patent 11052083 Transmucosal methods for treating psychiatric and neurological conditions
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US Patent 11053245 Methods
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US Patent 11331316 Amorphous solid dispersions
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US Patent 11311536 Amorphous solid dispersions
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US Patent 11376249 Organic compounds
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US Patent 11407751 Hydrochloric acid salt of (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
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US Patent 11427587 Organic compounds
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US Patent 6849619 Substituted pyridoindoles as serotonin agonists and antagonists
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US Patent 6867298 Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
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US Patent 6888032 Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
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US Patent 6946560 Ligands for metals and improved metal-catalyzed processes based thereon
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US Patent 7026498 Ligands for metals and improved metal-catalyzed processes based thereon
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US Patent 7071186 Substituted heterocycle fused gamma-carbolines
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US Patent 7081455 Substituted heterocycle fused gamma-carbolines
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Patent Primary Examiner
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Umamaheswari Ramachandran
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CPC Code
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A61K 31/164
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A61K 31/131
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A61P 25/28
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A61K 31/4985
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A61K 31/473
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A61K 31/445
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