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US Patent 11993651 Anti-lag-3 antibodies and methods of use thereof

Patent 11993651 was granted and assigned to Agenus on May, 2024 by the United States Patent and Trademark Office.

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 US Patent 11993651 Anti-lag-3 antibodies and methods of use thereof

Article

Patent abstract

The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Agenus
Agenus
0
Current Assignee
Agenus
Agenus
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119936510
Patent Inventor Names
Cornelia Anne Mundt0
David Adam Savitsky0
Marc van Dijk0
Nicholas Stuart Wilson0
Shawn Michael Jennings0
Date of Patent
May 28, 2024
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Patent Application Number
171000380
Date Filed
November 20, 2020
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Patent Citations
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US Patent 7183076 Method for making multispecific antibodies having heteromultimeric and common components
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US Patent 7332582 Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
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US Patent 7411057 Nucleic acids encoding human monoclonal antibodies to CTLA-4
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US Patent 7488802 Antibodies against PD-1
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US Patent 7658921 Molecules with extended half-lives, compositions and uses thereof
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US Patent 7709226 Method of humanizing antibodies by matching canonical structure types CDRs
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US Patent 7858589 Compositions of CpG and saponin adjuvants and uses thereof
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US Patent 7943743 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
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US Patent 7951917 Method for making multispecific antibodies having heteromultimeric and common components
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US Patent 7972993 Identification of protein binding sites
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US Patent 8088449 Reinforced silicone resin film and method of preparing same
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US Patent 8114845 Compositions of PD-1 antagonists and methods of use
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US Patent 8168179 Treatment method using anti-PD-L1 antibody
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US Patent 8168757 PD-1 binding proteins
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US Patent 8217149 Anti-PD-L1 antibodies, compositions and articles of manufacture
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US Patent 8227577 Bivalent, bispecific antibodies
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US Patent 8354509 Antibodies to human programmed death receptor PD-1
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US Patent 8354847 Electrometer with in-measurement range adjustment and methods thereof for measuring electrostatic charge
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US Patent 8586713 Readily isolated bispecific antibodies with native immunoglobulin format
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US Patent 8591886 Combination therapies employing GITR binding molecules
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US Patent 8686119 Variants of humanized immunomodulatory monoclonal antibodies
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US Patent 8697845 Antibodies specifically directed to a soluble form of CTLA-4
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US Patent 8735553 Anti-PD1 antibodies and their use as therapeutics and diagnostics
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US Patent 8747847 Monoclonal antibodies for tumor treatment
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US Patent 8779105 Monoclonal antibodies to programmed death 1 (PD-1)
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US Patent 8779108 Targeted binding agents against B7-H1
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US Patent 8927697 PD-1 specific antibodies and uses thereof
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US Patent 8981063 B7-H1 Antibodies
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US Patent 8993731 PD-1 antibody
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US Patent 9005629 Method for treating cancer with an antibody to CD223 protein
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US Patent 9074000 T cell receptor-like antibodies specific for a WT1 peptide presented by HLA-A2
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US Patent 9102727 Human anti-PD-1 antibodies and uses therefor
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US Patent 9132281 Focused radiation for augmenting immune-based therapies against neoplasms
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US Patent 9175082 Antigen binding proteins that bind PD-L1
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US Patent 9205148 Antibodies and other molecules that bind B7-H1 and PD-1
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US Patent 9244059 Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
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US Patent 9425591 ARC deflecting and ventilation assembly for electrical enclosures and systems for ARC deflecting and ventilation
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US Patent 9505839 Optimization of antibodies that bind lymphocyte activation gene-3 (LAG-3), and uses thereof
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US Patent 9515982 Method and apparatus for voice over LTE and data handling in a roaming environment
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US Patent 9850306 Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
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US Patent 9902772 Antibody therapeutics that bind LAG3
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US Patent 9908936 Antibody molecules to LAG-3 and uses thereof
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US Patent 10081681 Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
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US Patent 10144778 Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
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US Patent 10160806 Covalently bonded diabodies having immunoreactivity with PD-1 and LAG-3, and methods of use thereof
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US Patent 10188730 Anti-LAG3 antibodies and antigen-binding fragments
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US Patent 10844119 Anti-LAG-3 antibodies and methods of use thereof
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US Patent 10882908 Anti-LAG-3 antibodies and methods of use thereof
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US Patent 6984720 Human CTLA-4 antibodies
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US Patent 7029678 Vaccines
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US Patent 7034121 Antibodies against CTLA4
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Patent Primary Examiner
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Michail A Belyavskyi
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