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US Patent 12064430 Kinase inhibitor salts and compositions thereof

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 US Patent 12064430 Kinase inhibitor salts and compositions thereof

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Patent abstract

The present invention relates to cabozantinib lauryl sulfate salt and methods of use.

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
120644300
Patent Inventor Names
Chi-Cheng Lin0
Chin-Yao Yang0
Fang-Yu Liu0
K. C. Sung0
Li Qiao0
Yi-Hsin Lin0
Date of Patent
August 20, 2024
0
Patent Application Number
180965980
Date Filed
January 13, 2023
0
Patent Citations
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US Patent 11124481 Method of preparing fluorine-18 labeled Cabozantinib and its analogs
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US Patent 11124482 C-met modulators and methods of use
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US Patent 11098015 Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
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US Patent 11091439 Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
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US Patent 11091440 Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)- N′-(4-fluorophenyl)cyclopropane-1,1 -dicarboxamide, and crystalline forms thereof for the treatment of cancer
0
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US Patent 11141413 Method of treating renal cell carcinoma using N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, (2S)-hydroxybutanedioate
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US Patent 7087614 Pyrimidine inhibitors of phosphodiesterase (PDE) 7
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US Patent 7105530 Pyrimidineamines as angiogenesis modulators
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US Patent 7119093 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
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US Patent 7125875 Cyclic protein tyrosine kinase inhibitors
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US Patent 7153856 Cyclic protein tyrosine kinase inhibitors
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US Patent 7169771 Thiazolyl-based compounds useful as kinase inhibitors
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US Patent 7169791 Inhibitors of tyrosine kinases
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US Patent 7189854 Cyclic protein tyrosine kinase inhibitors
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US Patent 7262203 Pyrimidineamines as angiogenesis modulators
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US Patent 7265134 Tyrosine kinase inhibitors
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US Patent 7323482 Thiazolyl-based compounds useful as kinase inhibitors
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US Patent 7408069 Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives
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US Patent 7491725 Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
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US Patent 7575473 Connector
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US Patent 7622472 Combination of Src kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases
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US Patent 7622473 'N-(2-chloro-6-methylphenyl)-2-[[(6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites
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US Patent 7645778 Heteroaryl compounds as P2Y
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US Patent 7652146 Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
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US Patent 7666874 Pyrimidylaminobenzamide derivatives for hypereosinophilic syndrome
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US Patent 7709657 Process for the synthesis of organic compounds
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US Patent 7767688 Combination of pyrimidylaminobenzamide compounds and imatinib for treating gastrointestinal stromal tumours
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US Patent 7781597 Process for the synthesis of organic compounds
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US Patent 7798475 Device, method and use for the formation of small particles
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US Patent 7932386 Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives
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US Patent 7973045 Anhydrous form of dasatinib and process for preparation thereof
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US Patent 7977345 c-MET modulators and method of use
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US Patent 7989474 Use of Lck inhibitors for treatment of immunologic diseases
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US Patent 8007995 Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
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US Patent 8008504 Process for the synthesis of organic compounds
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US Patent 8017621 Inhibitors of the mutant form of kit
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US Patent 8067423 Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof
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US Patent 8067436 c-Met modulators and methods of use
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US Patent 8093259 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]-benzamide for treatment of melanoma
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US Patent 8114885 Chemical compounds
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US Patent 8124611 Inhibitors of the mutant form of kit
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US Patent 8124763 Process for the synthesis of 5-(methyl-1
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US Patent 8163904 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-Benzamide
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US Patent 8227477 Nilotinib HCl crystalline forms
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US Patent 8242270 Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
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US Patent 8247419 Methods of identifying and treating individuals exhibiting mutant kit protein
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US Patent 8293756 Pharmaceutical compositions comprising nilotinib hydrochloride monohydrate
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US Patent 8343984 Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 8389537 Salts of 4-methyl N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 8415363 Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 8426418 Method to treat melanoma in BRAF inhibitor-resistant subjects
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US Patent 8497284 C-met modulators and method of use
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US Patent 8501760 Pharmaceutical compositions comprising nilotinib or its salt
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US Patent 8580806 Salts of 4-methyl N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 8585942 Process and arrangement for producing particles utilizing subcritical fluids
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US Patent 8585943 Method and arrangement for the production of particles
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US Patent 8592442 Nilotinib HCl crystalline forms
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US Patent 8604045 Pyrimidylaminobenzamide derivatives for treatment of neurofibromatosis
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US Patent 8653093 Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases
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US Patent 8673912 Crystalline Forms on N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]-quinolin-4-yl}oxy)phenyl]-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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US Patent 8673930 Pyrimidylaminobenzamide derivatives for systemic mastocytosis
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US Patent 8680103 Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
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US Patent 8703788 Polymorph of nilotinib hydrochloride
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US Patent 8753674 Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
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US Patent 8815260 Treatment of restenosis and stenosis with dasatinib
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US Patent 8816077 Oligomer-protein tyrosine kinase inhibitor conjugates
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US Patent 8829015 Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 8877776 (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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US Patent 8884013 Polymorphs of Dasatinib, preparation methods and pharmaceutical compositions thereof
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US Patent 8937082 Nilotinib salts and crystalline forms thereof
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US Patent 8946416 Process for the synthesis of 5-(methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine
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US Patent 9061028 Process for the preparation of Nilotinib
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US Patent 9061029 Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
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US Patent 9084828 Oligomer-protein tyrosine kinase inhibitor conjugates
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US Patent 9090598 Nilotinib salts and crystalline forms thereof
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US Patent 9108954 Synthesis process of dasatinib and intermediate thereof
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US Patent 9115124 Process and intermediates for the preparation of dasatinib
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US Patent 9145406 Process for preparing dasatinib monohydrate
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US Patent 9163005 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
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US Patent 9168226 Injectable particle
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US Patent 9174947 c-Met modulators and methods of use
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US Patent 9187452 Method for preparing nilotinib
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US Patent 9249134 Process for preparation of amorphous form of dasatinib
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US Patent 9301957 Immediate release 4-methyl-3-4[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-YL)-3-(trifluoromethyl)phenyl] benzamide formulation
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US Patent 9340536 Multicomponent crystals comprising dasatinib and selected co-crystal formers
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US Patent 9365516 Process for preparing quinoline derivatives
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US Patent 9365526 Process for the preparation of dasatinib and its intermediates
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US Patent 9376419 Solid forms of nilotinib hydrochloride
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US Patent 9402918 Core-shell particle formulation for delivering multiple therapeutic agents
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US Patent 9440959 Process for the preparation of nilotinib
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US Patent 9456992 Pharmaceutical composition comprising stable, amorphous, hybrid nanoparticles of at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix forming component
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US Patent 9556164 Salts of Dasatinib in crystalline form
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US Patent 9566344 Dasatinib and nonlinear configuration polyethylene glycol conjugate
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US Patent 9567317 Multicomponent crystalline system comprising nilotinib and selected co-crystal formers
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US Patent 9623025 Treatment of mammalian disorders mediated by alpha-carbonic anhydrase isoforms
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US Patent 9682041 Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
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US Patent 9682081 Pharmaceutical gastro-retentive solid oral dosage form of nilotinib
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US Patent 9707265 Treatment of muscular dystrophy
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US Patent 9717720 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
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US Patent 9724342 C-met modulator pharmaceutical compositions
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US Patent 9751861 N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase
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US Patent 9809549 Malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
0
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US Patent 9815789 Polymorphs of cabozantinib (S)-malate and cabozantinib free base
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US Patent 9827230 Pharmaceutical compositions
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US Patent 9833442 Pharmaceutical compositions
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US Patent 9833443 Pharmaceutical compositions
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US Patent 9861624 Method of treating cancer
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US Patent 9884857 Salts of dasatinib in amorphous form
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US Patent 9907756 Capsule pharmaceutical dosage form comprising a suspension formulation of an indolinone derivative
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US Patent 9926296 Process for the preparation of polymorphic forms of nilotinib hydrochloride
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US Patent 9969692 Process for preparing quinoline derivatives
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US Patent 9981947 Polymorphic forms of nilotinib hydrochloride
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US Patent 10000470 Method for preparing nilotinib
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US Patent 10016423 Solid forms of nilotinib hydrochloride
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US Patent 10023566 Dasatinib salts
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US Patent 10034873 C-met modulator pharmaceutical compositions
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US Patent 10039757 C-Met modulator pharmaceutical compositions
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US Patent 10052307 Micellar nanocomplex
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US Patent 10053427 Crystalline forms of cabozantinib phosphate and cabozantinib hydrochloride
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US Patent 10076520 Use of tyrosine kinase inhibitor in cancer treatment
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US Patent 10080723 Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
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US Patent 10105323 Pharmaceutical dosage form for immediate release of an indolinone derivative
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US Patent 10117881 Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
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US Patent 10123999 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
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US Patent 10138221 Salts of nilotinib and polymorphs thereof
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US Patent 10143683 Pharmaceutical compositions
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US Patent 10150733 Amidoheteroaryl aroyl hydrazide ethynes
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US Patent 10154990 Medicaments for the treatment or prevention of fibrotic diseases
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US Patent 10159666 Dosing of cabozantinib formulations
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US Patent 10166225 Method for treating osteoporosis
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US Patent 10206916 Cabozantinib salts and their use as anti-cancer agents
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US Patent 10238602 Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
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US Patent 10253371 Method of treating leukemia based on gene expression of clock genes
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US Patent 10258691 Protective effect of DMPC, DMPG, DMPC/DMPG, EGPG, LysoPG and LysoPC against drugs that cause channelopathies
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US Patent 10260097 Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
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US Patent 10272102 Hydroxyalkyl starch for the treatment of hematological neoplasms
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US Patent 10314830 Pharmaceutical compositions
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US Patent 10280153 Process for the preparation of pure nilotinib and its salt
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US Patent 10273211 Metabolites of N-{4-([6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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US Patent 10301282 Polymorphic form X of nilotinib dihydrochloride hydrate
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US Patent 10301302 Crystalline forms of N-(2-chloro-6-methy]phenvn-2-[F6-[4-(2-hvdroxvethvl)-L-piperazin-vil-2-methvil-4-pvrimidinvllaminol-5-thiazolecarboxamide and their process thereof
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US Patent 10349884 Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
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US Patent 10357458 Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
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US Patent 10392351 Method for preparing nilotinib intermediate
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US Patent 10449193 Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
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US Patent 10501418 Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
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US Patent 10532045 Liposomal mitigation of drug-induced inhibition of the cardiac I
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US Patent 10543206 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
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US Patent 10548888 C-Met modulator pharmaceutical compositions
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US Patent 10736886 Methods of using c-Met modulators
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US Patent 10940149 Kinase inhibitor salts and compositions thereof
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US Patent 11007195 Kinase inhibitor salts, and compositions thereof
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US Patent 11052088 Kinase inhibitor salts, and compositions thereof
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US Patent 11065240 Drug combinations to treat multiple myeloma
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US Patent 11261160 Process for the preparation of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide, (2S)-hydroxybutanedioate and its polymorphs thereof
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US Patent 11498902 Process for the preparation of Cabozantinib and its pharmaceutically acceptable salts thereof
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Patent Primary Examiner
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Jared Barsky
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CPC Code
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A61K 9/48
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A61K 9/20
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A61K 9/0053
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A61P 35/02
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A61K 31/506
0

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