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US Patent 12104165 Adeno-associated virus with engineered capsid

Patent 12104165 was granted and assigned to Tenaya Therapeutics on October, 2024 by the United States Patent and Trademark Office.

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 US Patent 12104165 Adeno-associated virus with engineered capsid

Article

Patent abstract

The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein identified using a high-throughput sequencing screen or rational design. In particular, the disclosure provides AAV5 virions and capsid proteins with increased transduction efficiency in cardiac cells, increased cell-type selectivity, and/or other desirable properties.

Infobox
Is a
Patent
Patent
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Patent Applicant
Tenaya Therapeutics
Tenaya Therapeutics
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Current Assignee
Tenaya Therapeutics
Tenaya Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121041650
Patent Inventor Names
Christopher A. Reid0
Date of Patent
October 1, 2024
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Patent Application Number
184936630
Date Filed
October 24, 2023
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Patent Citations
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US Patent 11118192 Adeno-associated virus variant capsids and methods of use thereof
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US Patent 7091029 High titer recombinant AAV production
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US Patent 7105345 Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
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US Patent 7198951 Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
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US Patent 7259151 AAV virions with decreased immunoreactivity and uses therefor
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US Patent 7718424 AAV4 vector and uses thereof
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US Patent 7790449 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing the same, and uses therefor
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US Patent 7867484 Heparin and heparan sulfate binding chimeric vectors
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US Patent 7906111 Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
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US Patent 8119119 Non-integrative and non-replicative lentivirus, preparation and uses thereof
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US Patent 8524446 Method for detecting adeno-associated virus
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US Patent 8679837 Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors
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US Patent 8784799 Duplexed parvovirus vectors
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US Patent 8906675 Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
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US Patent 8999678 Method of increasing the function of an AAV vector
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US Patent 9169494 Restrictive inverted terminal repeats for viral vectors
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US Patent 9233131 Mutant adeno-associated virus virions and methods of use thereof
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US Patent 9434928 Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
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US Patent 9441206 Cell line for production of adeno-associated virus
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US Patent 9447433 Synthetic adeno-associated virus inverted terminal repeats
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US Patent 9737618 Adeno-associated virus (AAV) glades, sequences, vectors containing same, and uses therefor
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US Patent 9783824 Self-complementary parvoviral vectors, and methods for making and using the same
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US Patent 9790472 Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
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US Patent 10036016 Methods for inducing glucose uptake
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US Patent 10046016 Mutant adeno-associated virus virions and methods of use thereof
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US Patent 10214566 Mutant adeno-associated virus virions and methods of use thereof
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US Patent 10485883 Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
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US Patent 10526617 Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
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US Patent 10550405 Rational polyploid adeno-associated virus vectors and methods of making and using the same
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US Patent 10934560 Rational polyploid adeno-associated virus vectors for the treatment of disease
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US Patent 11384364 Methods of enhancing biological potency of baculovirus system-produced recombinant adeno-associated virus
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US Patent 11566243 Compositions and methods for treatment of cardiac diseases
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US Patent 11781156 Plakophillin-2 gene therapy methods and compositions
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US Patent 6910434 Control device for steering kite on a boat
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US Patent 6962815 AAV2 vectors and methods
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US Patent 6984517 AAV5 vector and uses thereof
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US Patent 6995009 Packaging cell
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US Patent 7070994 Packaging cells
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Patent Primary Examiner
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Maria Marvich
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