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US Patent 12129467 Non-liposomal systems for nucleic acid delivery

Patent 12129467 was granted and assigned to Arbutus Biopharma Corporation on October, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Arbutus Biopharma Corporation
Arbutus Biopharma Corporation
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Current Assignee
Arbutus Biopharma Corporation
Arbutus Biopharma Corporation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121294670
Patent Inventor Names
Lloyd B. Jeffs0
Lorne R. Palmer0
Ed Yaworski0
Date of Patent
October 29, 2024
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Patent Application Number
184101360
Date Filed
January 11, 2024
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Patent Citations
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US Patent 7514099 Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
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US Patent 7601872 Transfection reagents
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US Patent 7687070 Reagents for intracellular delivery of macromolecules
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US Patent 7745651 Cationic lipids and methods of use
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US Patent 7799565 Lipid encapsulated interfering RNA
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US Patent 7803397 Polyethyleneglycol-modified lipid compounds and uses thereof
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US Patent 7807815 Compositions comprising immunostimulatory siRNA molecules and DLinDMA or DLenDMA
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US Patent 7838658 siRNA silencing of filovirus gene expression
0
...
Patent Primary Examiner
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Kimberly Chong
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Patent abstract

The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.

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