Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Lisa Marie Newman0
Anke Kebber0
Gjalt W. Huisman0
S. Christopher Davis0
Stephane J. Jenne0
Date of Patent
December 8, 2009
0Patent Application Number
109163110
Date Filed
August 11, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
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