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US Patent 7659442 Method for making homozygous genetic modifications

Patent 7659442 was granted and assigned to Regeneron Pharmaceuticals, Inc. on February, 2010 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

David Frendewey0

Thomas M. DeChiara0

William Poueymirou0

Wojtek Auerbach0

David M. Valenzuela0

Date of Patent

February 9, 2010

Patent Application Number

11904558

Date Filed

September 27, 2007

Patent Citations Received

US Patent 12127537 Genetically modified non-human animals and methods of use thereof

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US Patent 11889821 Enhanced immunoglobulin diversity

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US Patent 11910787 Rodents having a humanized TMPRSS gene

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US Patent 11957115 Genetically modified mouse expressing human APOE4 and mouse Trem2 p.R47H and methods of use thereof

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US Patent 11963521 Humanized IL-4 and IL-4Rα animals

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US Patent 12010979 Non-human animals comprising a humanized TTR locus and methods of use

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US Patent 12089576 Nucleic acids comprising a modified rodent activin a receptor type 1 (Acvr1) gene

0

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Patent Primary Examiner

Patent abstract

Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.

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