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US Patent 9512446 Engineered CRISPR-Cas9 nucleases

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US Patent 12133884 Methods of substituting pathogenic amino acids using programmable base editor systems

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US Patent 12123032 CRISPR enzyme mutations reducing off-target effects

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US Patent 12110545 Methods of assessing nuclease cleavage

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US Patent 12104207 Genomewide unbiased identification of DSBs evaluated by sequencing (GUIDE-Seq)

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US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing

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US Patent 12065668 RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci

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US Patent 12018275 Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy

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US Patent 12006520 Evaluation and improvement of nuclease cleavage specificity

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US Patent 11999947 Adenosine nucleobase editors and uses thereof

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US Patent 11976324 Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents

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US Patent 11932884 High efficiency base editors comprising Gam

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US Patent 11920181 Nuclease profiling system

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US Patent 11912985 Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

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US Patent 11913014 None

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US Patent 11911415 CRISPR/Cas-related methods and compositions for improving transplantation

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US Patent 11866726 Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites

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Edits on 5 Dec, 2023

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Patent abstract

Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.

Edits on 19 Jul, 2023

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Patent Citations Received

US Patent 11702651 Adenosine nucleobase editors and uses thereof

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