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US Patent 10294281 High-transduction-efficiency rAAV vectors, compositions, and methods of use

Patent 10294281 was granted and assigned to University of Florida on May, 2019 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

University of Florida

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Current Assignee

University of Florida

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

George Vladimirovich Aslanidi0

Arun Srivastava0

Kim M. Van Vliet0

Mavis Agbandje-McKenna0

Date of Patent

May 21, 2019

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Patent Application Number

154442350

Date Filed

February 27, 2017

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Patent Citations Received

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US Patent 10934327 Capsid-modified, RAAV3 vector compositions and uses in gene therapy of human liver cancer

US Patent 11802293 Adeno-associated virus vector

US Patent 11434260 High-transduction-efficiency rAAV vectors, compositions, and methods of use

Patent Primary Examiner

Janet L. Andres

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Patent abstract

The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.

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