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US Patent 10294281 High-transduction-efficiency rAAV vectors, compositions, and methods of use

Patent 10294281 was granted and assigned to University of Florida on May, 2019 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 12065467 High-transduction-efficiency rAAV vectors, compositions, and methods of use
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Patent abstract

The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.

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US Patent 11802293 Adeno-associated virus vector
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Patent Inventor Names
Arun Srivastava0
George Vladimirovich Aslanidi0
Kim M. Van Vliet0
Mavis Agbandje-McKenna0
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=102942810
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Infobox
Is a
Patent
Patent
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Patent Applicant
University of Florida
University of Florida
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Current Assignee
University of Florida
University of Florida
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
102942810
Date of Patent
May 21, 2019
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Patent Application Number
154442350
Date Filed
February 27, 2017
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=102942810
Patent Citations Received
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US Patent 10648000 rAAV vector compositions, methods for targeting vascular endothelial cells and use in treatment of type I diabetes
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US Patent 10723768 Capsid modified rAAV vectors and methods of use
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US Patent 10815279 Capsid-modified rAAV vector compositions and methods therefor
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US Patent 10927150 Recombinant AAV1, AAV5, and AAV6 capsid mutants and uses thereof
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US Patent 10934327 Capsid-modified, RAAV3 vector compositions and uses in gene therapy of human liver cancer
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US Patent 11434260 High-transduction-efficiency rAAV vectors, compositions, and methods of use
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Patent Primary Examiner
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Janet L. Andres
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US Patent 11434260 High-transduction-efficiency rAAV vectors, compositions, and methods of use
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Website URL
https://pdfpiw.uspto.gov/.piw?Docid=10294281
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Patent citations received
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US Patent 10927150 Recombinant AAV1, AAV5, and AAV6 capsid mutants and uses thereof
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Patent citations received
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US Patent 10815279 Capsid-modified rAAV vector compositions and methods therefor

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