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US Patent 11421014 Trifunctional T cell-antigen coupler and methods and uses thereof

Patent 11421014 was granted and assigned to McMaster University on August, 2022 by the United States Patent and Trademark Office.

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A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

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