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US Patent 11421014 Trifunctional T cell-antigen coupler and methods and uses thereof

Patent 11421014 was granted and assigned to McMaster University on August, 2022 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 12016923 Claudin 18.2 T cell-antigen couplers and uses thereof
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US Patent 11976117 T cell-antigen coupler with various construct optimizations
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US Patent 11970545 T cell-antigen coupler with Y182T mutation and methods of uses thereof
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US Patent 11878035 T cell-antigen coupler with various construct optimizations
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Christopher W. Helsen0
Galina Denisova0
Jonathan Bramson0
Kenneth Mwawasi0
Rajanish Giri0
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 US Patent 11421014 Trifunctional T cell-antigen coupler and methods and uses thereof

Article

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Infobox
Is a
Patent
Patent
Patent Applicant
McMaster University
McMaster University
Current Assignee
McMaster University
McMaster University
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11421014
Date of Patent
August 23, 2022
Patent Application Number
16547421
Date Filed
August 21, 2019
Patent Citations
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US Patent 11111298 T cell-antigen coupler with various construct optimizations
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US Patent 11198737 T cell-antigen coupler with Y177 mutation and methods of uses thereof
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US Patent 10435453 Trifunctional T cell-antigen coupler and methods and uses thereof
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US Patent 10640562 T cell-antigen coupler with various construct optimizations
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US Patent 10822408 PACAP antibodies and uses thereof
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US Patent 11001621 Trifunctional T cell-antigen coupler and methods and uses thereof
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US Patent 11008376 Trifunctional T cell-antigen coupler and methods and uses thereof
Patent Primary Examiner
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Arthur S Leonard

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