Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Dhruva Katrekar0
Prashant Mali0
Date of Patent
March 19, 2024
0Patent Application Number
164904940
Date Filed
March 2, 2018
0Patent Citations
Patent Primary Examiner
Patent abstract
Aspects of the disclosure relate to a gene therapy approach for diseases, disorders, or conditions caused by mutation in the stop codon utilizing modified tRNA. At least 10-15% of all genetic diseases, including muscular dystrophy (e.g. Duchene muscular dystrophy), some cancers, beta thalassemia, Hurler syndrome, and cystic fibrosis, fall into this category. Not to be bound by theory, it is believed that this approach is safer than CRISPR approaches due to minimal off-target effects and the lack of genome level changes.
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