US Patent 11708390 Method of storing a separation matrix
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US Patent 11708390 Method of storing a separation matrix
Article
The present invention concerns a method of storing a separation matrix comprising multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support. The method comprises the steps of: a) providing a storage liquid comprising at least 50% by volume of an aqueous alkali metal hydroxide solution; b) permeating the separation matrix with the storage liquid; and c) storing the storage liquid-permeated separation matrix for a storage time of at least days. The alkali-stabilized Protein A domains comprise mutants of a parental Fc-binding domain of
Infobox
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Patent Jurisdiction
Patent Number
117083900
Date of Patent
July 25, 2023
0Patent Application Number
160957210
Date Filed
May 10, 2017
0Patent Citations
Patent Primary Examiner
CPC Code
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