US Patent 11753438 Method of cleaning and/or sanitizing a separation matrix
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US Patent 11753438 Method of cleaning and/or sanitizing a separation matrix
Article
The present invention concerns a method of cleaning and/or sanitizing a separation matrix comprising multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support. The method comprises the steps of: a) optionally purifying a mixture comprising a first immunoglobulin using the separation matrix; b) providing a cleaning liquid comprising at least 50% by volume of an aqueous alkali metal hydroxide solution; and c) cleaning and/or sanitizing the separation matrix by contacting the cleaning liquid with the separation matrix for a predetermined contact time. The alkali-stabilized Protein A domains comprise mutants of a parental Fc-binding domain of
Infobox
Is a
Patent Jurisdiction
Patent Number
11753438
Patent Inventor Names
Annika Forss
Gustav José Rodrigo
Jesper Ulf Hansson
Mats Ander
Tomas Bjorkman
Date of Patent
September 12, 2023
Patent Application Number
16095753
Date Filed
May 10, 2017
Patent Citations
Patent Primary Examiner
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