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US Patent 12084655 Packaging oligonucleotides into virus-like particles

Patent 12084655 was granted and assigned to Checkmate Pharmaceuticals on September, 2024 by the United States Patent and Trademark Office.

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 US Patent 12084655 Packaging oligonucleotides into virus-like particles

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Patent abstract

The present invention relates to processes for producing compositions comprising (i) a virus-like particle of an RNA bacteriophage, and (ii) aggregated oligonucleotides, wherein said aggregated oligonucleotides are packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising aggregated oligonucleotides suitable for use in the aforementioned processes before. Moreover, the invention further provides nucleotide compositions comprising aggregated oligonucleotides. Furthermore, the invention further provides compositions comprising (i) a virus-like particle of an RNA bacteriophage, and (ii) aggregated oligonucleotides, wherein said aggregated oligonucleotides are packaged into said virus-like particle.

Infobox
Is a
Patent
Patent
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Patent Applicant
Checkmate Pharmaceuticals
Checkmate Pharmaceuticals
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Current Assignee
Checkmate Pharmaceuticals
Checkmate Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120846550
Patent Inventor Names
Evan David Walters0
Frank Hennecke0
Date of Patent
September 10, 2024
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Patent Application Number
170459290
Date Filed
April 8, 2019
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Patent Citations
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US Patent 7410975 Small molecule toll-like receptor (TLR) antagonists
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US Patent 7488802 Antibodies against PD-1
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US Patent 7521063 Multiple CPG oligodeoxynucleotides and their use to induce an immune response
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US Patent 7566703 Semi-soft C-class immunostimulatory oligonucleotides
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US Patent 7605238 Human CTLA-4 antibodies and their uses
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US Patent 7635468 Allogeneic tumor therapeutic agent, a vaccine using allogeneic tumor cells for the therapeutic treatment of tumor diseases, and a method for the making of such a vaccine, and transfected human tumor cells for use as a vaccine
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US Patent 7776344 Methods related to immunostimulatory nucleic acid-induced interferon
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US Patent 7795235 Semi-soft c-class immunostimulatory oligonucleotides
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US Patent 7888098 Scalable process for protein purification
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US Patent 7892569 Methods of altering an immune response induced by CpG oligodeoxynucleotides
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US Patent 7943743 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
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US Patent 8283328 Immunostimulatory nucleic acids
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US Patent 8450467 Carbohydrate conjugates as delivery agents for oligonucleotides
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US Patent 8574564 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
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US Patent 8580268 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity
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US Patent 8691209 Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
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US Patent 8940310 Methods of treatment using TLR7 and/or TLR9 inhibitors
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US Patent 8962579 Methods and compositions for inhibition of immune responses and autoimmunity
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US Patent 8987221 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9
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US Patent 9126996 Immune system modulators
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US Patent 9139554 Amino lipids and methods for the delivery of nucleic acids
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US Patent 9206430 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
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US Patent 9220683 Lipids and compositions for the delivery of therapeutics
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US Patent 9260719 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
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US Patent 9404126 Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages
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US Patent 9518095 Scalable fermentation process
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US Patent 10682365 Combination tumor immunotherapy
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US Patent 10751512 Intravenous (IV) catheter apparatus
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US Patent 6849725 Covalently closed nucleic acid molecules for immunostimulation
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US Patent 6949520 Methods related to immunostimulatory nucleic acid-induced interferon
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US Patent 7074772 Design principle for the construction of expression constructs for gene therapy
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Patent Primary Examiner
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Patrick T. Lewis
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