Log in
Sign up
Golden has been acquired by ComplyAdvantage.Read about it here ⟶
‌

US Patent 12121592 Lipid nanoparticle compositions and methods for mRNA delivery

Patent 12121592 was granted and assigned to Translate Bio on October, 2024 by the United States Patent and Trademark Office.

OverviewStructured DataIssuesContributorsActivity

All edits

Edits on 23 Oct, 2024
"Created via: Patent importer"
Golden AI profile picture
Golden AI
created this topic on 23 Oct, 2024
Edits made to:
Infobox (+173 properties)
Article (+252 characters)
‌

 US Patent 12121592 Lipid nanoparticle compositions and methods for mRNA delivery

Article

Patent abstract

Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Translate Bio
Translate Bio
0
Current Assignee
Translate Bio
Translate Bio
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
121215920
Patent Inventor Names
Braydon Charles Guild0
Frank DeRosa0
Michael Heartlein0
Date of Patent
October 22, 2024
0
Patent Application Number
178321960
Date Filed
June 3, 2022
0
Patent Citations
‌
US Patent 7094423 Methods for preparation of lipid-encapsulated therapeutic agents
0
‌
US Patent 7341738 Lipid-encapsulated polyanionic nucleic acid
0
‌
US Patent 7381422 Method for producing sterile polynucleotide based medicaments
0
‌
US Patent 7410795 Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
0
‌
US Patent 7422902 Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
0
‌
US Patent 7427394 Biodegradable poly(β-amino esters) and uses thereof
0
‌
US Patent 7507859 Functional synthetic molecules and macromolecules for gene delivery
0
‌
US Patent 11185595 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 7521187 Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
0
‌
US Patent 7537768 Influenza virus vaccine composition and methods of use
0
‌
US Patent 7556684 Amine containing strength improvement admixture
0
‌
US Patent 7745651 Cationic lipids and methods of use
0
‌
US Patent 7785603 Influenza virus vaccine composition and methods of use
0
‌
US Patent 7803397 Polyethyleneglycol-modified lipid compounds and uses thereof
0
‌
US Patent 7888067 Recombinant human factor IX and use thereof
0
‌
US Patent 7888112 Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
0
‌
US Patent 7901708 Liposomal apparatus and manufacturing methods
0
‌
US Patent 7972435 Amine containing strength improvement admixture
0
‌
US Patent 8021686 Lipid-encapsulated polyanionic nucleic acid
0
‌
US Patent 8071082 End-modified poly(beta-amino esters) and uses thereof
0
‌
US Patent 8101741 Modified siRNA molecules and uses thereof
0
‌
US Patent 8106022 Carbohydrate conjugates as delivery agents for oligonucleotides
0
‌
US Patent 8128938 Influenza virus vaccine composition and methods of use
0
‌
US Patent 8158601 Lipid formulation
0
‌
US Patent 8188263 Modified siRNA molecules and uses thereof
0
‌
US Patent 8236943 Compositions and methods for silencing apolipoprotein B
0
‌
US Patent RE43612 Biodegradable poly(β-amino esters) and uses thereof
0
‌
US Patent 8278036 RNA containing modified nucleosides and methods of use thereof
0
‌
US Patent 8278093 Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
0
‌
US Patent 8287849 Biodegradable poly(beta-amino esters) and uses thereof
0
‌
US Patent 8329070 Liposomal apparatus and manufacturing method
0
‌
US Patent 8435557 Method for producing sterile polynucleotide based medicaments
0
‌
US Patent 8450298 Aminoalcohol lipidoids and uses thereof
0
‌
US Patent 8450467 Carbohydrate conjugates as delivery agents for oligonucleotides
0
‌
US Patent 8513403 Modified siRNA molecules and uses thereof
0
‌
US Patent 8557231 Biodegradable poly(beta-amino esters) and uses thereof
0
‌
US Patent 8562966 End-modified poly(beta-amino esters) and uses thereof
0
‌
US Patent 8569256 Cationic lipids and methods for the delivery of therapeutic agents
0
‌
US Patent 8647864 Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
0
‌
US Patent 8652512 Nebulized liposomes for the pulmonary application of drug compounds
0
‌
US Patent 8673317 Codon-optimized polynucleotide-based vaccines against human
0
‌
US Patent 8691966 RNA containing modified nucleosides and methods of use thereof
0
‌
US Patent 8710200 Engineered nucleic acids encoding a modified erythropoietin and their expression
0
‌
US Patent 8715999 Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines
0
‌
US Patent 8748089 RNA containing modified nucleosides and methods of use thereof
0
‌
US Patent 8802644 Lipid formulation
0
‌
US Patent 8808681 Crosslinked, degradable polymers and uses thereof
0
‌
US Patent 8808982 Compositions and methods for reprogramming eukaryotic cells
0
‌
US Patent 8821890 Influenza virus vaccine composition and methods of use
0
‌
US Patent 8822663 Engineered nucleic acids and methods of use thereof
0
‌
US Patent 8828956 Carbohydrate conjugates as delivery agents for oligonucleotides
0
‌
US Patent 8835108 RNA containing modified nucleosides and methods of use thereof
0
‌
US Patent 8846348 Kits and methods for generating 5′ capped RNA
0
‌
US Patent 8853377 mRNA for use in treatment of human genetic diseases
0
‌
US Patent 8859229 Transient transfection with RNA
0
‌
US Patent 8883202 Lipid compositions
0
‌
US Patent 8936942 Polyethyleneglycol-modified lipid compounds and uses thereof
0
‌
US Patent 8969353 Aminoalcohol lipidoids and uses thereof
0
‌
US Patent 8999351 Lipids and compositions for the delivery of therapeutics
0
‌
US Patent 8999950 Compositions and methods for silencing aldehyde dehydrogenase
0
‌
US Patent 9005930 Kits and methods for generating 5′ capped RNA
0
‌
US Patent 9012219 RNA preparations comprising purified modified RNA for reprogramming cells
0
‌
US Patent 9012498 Biodegradable lipids for the delivery of active agents
0
‌
US Patent 9018187 Cationic lipids and methods for the delivery of therapeutic agents
0
‌
US Patent 9040256 Transposon end compositions and methods for modifying nucleic acids
0
‌
US Patent 9051567 Methods for increasing efficacy of lipid formulated siRNA
0
‌
US Patent 9061021 mRNA for use in treatment of human genetic diseases
0
‌
US Patent 9061059 Modified polynucleotides for treating protein deficiency
0
‌
US Patent 9074208 Modified siRNA molecules and uses thereof
0
‌
US Patent 9080211 Transposon end compositions and methods for modifying nucleic acids
0
‌
US Patent 9085801 Transposon end compositions and methods for modifying nucleic acids
0
‌
US Patent 9089604 Modified polynucleotides for treating galactosylceramidase protein deficiency
0
‌
US Patent 9095552 Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1
0
‌
US Patent 9107886 Modified polynucleotides encoding basic helix-loop-helix family member E41
0
‌
US Patent 9114113 Modified polynucleotides encoding citeD4
0
‌
US Patent 9180162 Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
0
‌
US Patent 9181319 Engineered nucleic acids and methods of use thereof
0
‌
US Patent 9181321 CFTR mRNA compositions and related methods and uses
0
‌
US Patent 9186325 Lipids and compositions for the delivery of therapeutics
0
‌
US Patent 9186372 Split dose administration
0
‌
US Patent 9187748 Compositions and methods for silencing ebola virus gene expression
0
‌
US Patent 9192651 Modified polynucleotides for the production of secreted proteins
0
‌
US Patent 9220682 Nanocarrier therapy for treating invasive tumors
0
‌
US Patent 9220755 Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
0
‌
US Patent 9220792 Modified polynucleotides encoding aquaporin-5
0
‌
US Patent 9233141 Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
0
‌
US Patent 9254265 Small liposomes for delivery of immunogen encoding RNA
0
‌
US Patent 9254311 Modified polynucleotides for the production of proteins
0
‌
US Patent 9295646 Cationic oil-in-water emulsions
0
‌
US Patent 9295689 Formulation and delivery of PLGA microspheres
0
‌
US Patent 9301923 Lipids, lipid compositions, and methods of using them
0
‌
US Patent 9301993 Modified polynucleotides encoding apoptosis inducing factor 1
0
‌
US Patent 9303079 Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
0
‌
US Patent 9326940 Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same
0
‌
US Patent 9334328 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
0
‌
US Patent 9345780 Site specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
0
‌
US Patent 9352042 Trialkyl cationic lipids and methods of use thereof
0
‌
US Patent 9352048 Carbohydrate conjugates as delivery agents for oligonucleotides
0
‌
US Patent 9364435 Lipid formulations for nucleic acid delivery
0
‌
US Patent 9394234 Lipid formulations
0
‌
US Patent 9404127 Non-liposomal systems for nucleic acid delivery
0
‌
US Patent 9428535 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
0
‌
US Patent 9428751 Compositions and methods for silencing apolipoprotein C-III expression
0
‌
US Patent 9464124 Engineered nucleic acids and methods of use thereof
0
‌
US Patent 9492386 Liposomal apparatus and manufacturing methods
0
‌
US Patent 9504651 Lipid compositions for nucleic acid delivery
0
‌
US Patent 9504734 Modified polynucleotides for the production of nuclear proteins
0
‌
US Patent 9518272 Non-liposomal systems for nucleic acid delivery
0
‌
US Patent 9572874 Composition comprising a complexed (M)RNA and a naked mRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof
0
‌
US Patent 9572896 In vivo production of proteins
0
‌
US Patent 9572897 Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
0
‌
US Patent 9587003 Modified polynucleotides for the production of oncology-related proteins and peptides
0
‌
US Patent 9616084 Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
0
‌
US Patent 9623095 Vaccination in newborns and infants
0
‌
US Patent 9636301 In vitro release assay for liposome encapsulated vincristine
0
‌
US Patent 9636410 Cationic oil-in-water emulsions
0
‌
US Patent 9655845 Oil-in-water emulsions that contain nucleic acids
0
‌
US Patent 9657295 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
0
‌
US Patent 9669089 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
0
‌
US Patent 9675668 Modified polynucleotides encoding hepatitis A virus cellular receptor 2
0
‌
US Patent 9682139 Lipids and compositions for the delivery of therapeutics
0
‌
US Patent 9683233 Artificial nucleic acid molecules for improved protein or peptide expression
0
‌
US Patent 9688729 Respiratory syncytial virus (RSV) vaccine
0
‌
US Patent 9770463 Delivery of RNA to different cell types
0
‌
US Patent 9801897 Delivery of RNA to trigger multiple immune pathways
0
‌
US Patent 9877919 Lipid-derived neutral nanoparticles
0
‌
US Patent 10064959 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
0
‌
US Patent 10183074 Cationic oil-in-water emulsions
0
‌
US Patent 10238733 Cationic oil-in-water emulsions
0
‌
US Patent 10238754 Lipid nanoparticle compositions and methods for MRNA delivery
0
‌
US Patent 10307374 Oil-in-water emulsions that contain nucleic acids
0
‌
US Patent 10350303 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 10413618 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 10487332 Immunisation of large mammals with low doses of RNA
0
‌
US Patent 10493167 In vivo production of proteins
0
‌
US Patent 10507249 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 10532067 Delivery of RNA to trigger multiple immune pathways
0
‌
US Patent 10577403 Modified polynucleotides for the production of secreted proteins
0
‌
US Patent 10583203 In vivo production of proteins
0
‌
US Patent 10703789 Modified polynucleotides for the production of secreted proteins
0
‌
US Patent 10772975 Modified Polynucleotides for the production of biologics and proteins associated with human disease
0
‌
US Patent 10888626 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 10898574 Delivery and formulation of engineered nucleic acids
0
‌
US Patent 10959953 Lipid formulations for delivery of messenger RNA
0
‌
US Patent 11026890 Oil-in-water emulsions that contain nucleic acids
0
‌
US Patent 11026964 Delivery of RNA to different cell types
0
‌
US Patent 11052159 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 11058762 Immunogenic compositions and uses thereof
0
‌
US Patent 11291635 Virion-like delivery particles for self-replicating RNA molecules
0
‌
US Patent 11291682 Delivery of RNA to trigger multiple immune pathways
0
‌
US Patent 11291734 Lipid nanoparticle compositions and methods for mRNA delivery
0
‌
US Patent 6858224 Method of preventing aggregation of a lipid:nucleic acid complex
0
‌
US Patent 6858225 Lipid-encapsulated polyanionic nucleic acid
0
‌
US Patent 6887665 Methods of array synthesis
0
‌
US Patent 6890554 Genetic immunization with cationic lipids
0
‌
US Patent 6974589 Neutral-cationic lipid for nucleic acid and drug delivery
0
‌
US Patent 6998115 Biodegradable poly(β-amino esters) and uses thereof
0
‌
US Patent 7002042 Cationic liposomes for gene transfer
0
‌
US Patent 7022214 Carrier ampholytes of high pH range
0
‌
US Patent 7067697 Cationic liposomes for gene transfer
0
‌
US Patent 7084303 Tertiary amine compounds having an ester structure and processes for preparing same
0
Patent Primary Examiner
‌
Robert M Kelly
0

Find more entities like US Patent 12121592 Lipid nanoparticle compositions and methods for mRNA delivery

Use the Golden Query Tool to find similar entities by any field in the Knowledge Graph, including industry, location, and more.
Open Query Tool
Access by API
Golden Query Tool
Golden logo